To assess incidence charges (IRs) of VTE in patients with rheumatoid arthritis (RA) on completely different DMARDs and DMARD switchers.Adults with RA on a DMARD between 2007 and 2017 have been studied in a US claims database.
Conventional synthetic DMARD (csDMARD) customers, first biologic/targeted synthetic DMARD (b/tsDMARD) customers and b/tsDMARD switchers (from a b/tsDMARD to a different b/tsDMARD) have been adopted for inpatient VTE (pulmonary embolism (PE)/deep vein thrombosis (DVT)).
Crude and adjusted IR and 95% CIs of VTE have been estimated. HRs for VTE have been estimated through Cox regression. VTE danger was additionally evaluated by quantity of switches between b/tsDMARDs and in patients and not using a VTE historical past.
The age and intercourse standardised IR (95% CI) of VTE (per 100 person-years) was 0.86 (0.70 to 1.03), 0.60 (0.52 to 0.68) and 0.58 (0.51 to 0.65) for b/tsDMARD switchers, first b/tsDMARD customers and csDMARD customers, respectively. After adjustment, b/tsDMARD switchers had an elevated danger of VTE, in contrast with csDMARD customers, HRadj (95% CI) being 1.36 (1.16 to 1.58), 1.36 (1.13 to 1.63) and 1.47 (1.18 to 1.83) for VTE, DVT and PE, respectively.
Compared with first b/tsDMARD customers, the HRadj (95% CI) for VTE was 1.35 (1.15 to 1.60) for first b/tsDMARD switchers and 1.48 (1.19 to 1.85) for second b/tsDMARD switchers.In RA, b/tsDMARD switchers have the next VTE danger in contrast with csDMARD customers and first b/tsDMARD customers.
Serologically Defined Colon Cancer Antigen 3 (SDCCAG3) Antibody |
|||
abx237665-100ug | Abbexa | 100 ug | EUR 610.8 |
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
abx237666-100ug | Abbexa | 100 ug | EUR 577.2 |
Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody |
|||
20-abx213359 | Abbexa |
|
|
Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody |
|||
20-abx213492 | Abbexa |
|
|
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
20-abx121727 | Abbexa |
|
|
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
20-abx325189 | Abbexa |
|
|
Serologically Defined Colon Cancer Antigen 3 (SDCCAG3) Antibody |
|||
20-abx115457 | Abbexa |
|
|
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
20-abx115458 | Abbexa |
|
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Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
abx029545-400ul | Abbexa | 400 ul | EUR 627.6 |
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
abx029545-80l | Abbexa | 80 µl | EUR 343.2 |
Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody |
|||
20-abx334226 | Abbexa |
|
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Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
abx432203-200ul | Abbexa | 200 ul | EUR 460.8 |
Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) Antibody |
|||
abx432204-200ul | Abbexa | 200 ul | EUR 343.2 |
Serologically Defined Colon Cancer Antigen 3 (SDCCAG3) Antibody |
|||
20-abx005975 | Abbexa |
|
|
Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody (HRP) |
|||
20-abx337646 | Abbexa |
|
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Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody (FITC) |
|||
20-abx337647 | Abbexa |
|
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Serologically defined colon cancer antigen 3 (SDCCAG3) Antibody (Biotin) |
|||
20-abx337648 | Abbexa |
|
|
anti- IDI1 antibody |
|||
FNab04124 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against IDI1 |
anti- IDI2 antibody |
|||
FNab04125 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against IDI2 |
anti- DEF6 antibody |
|||
FNab02325 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against DEF6 |
ELISA kit for Human Serologically defined colon cancer antigen 3 |
|||
EK3827 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Serologically defined colon cancer antigen 3 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Cow Serologically defined colon cancer antigen 3 (SDCCAG3) ELISA Kit |
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abx517987-96tests | Abbexa | 96 tests | EUR 1093.2 |
Anti-IBP / DEF6 antibody |
|||
STJ70543 | St John's Laboratory | 100 µg | EUR 430.8 |
anti- DEFA1 antibody |
|||
FNab02326 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against DEFA1 |
anti- DEFB1 antibody |
|||
FNab02327 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against DEFB1 |
Human Serologically defined colon cancer antigen 3 (SDCCAG3) ELISA Kit |
|||
abx251171-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Serologically Defined Colon Cancer Antigen 8 (SDCCAG8) ELISA Kit |
|||
abx383072-96tests | Abbexa | 96 tests | EUR 1093.2 |
Mouse Serologically defined colon cancer antigen 3 (SDCCAG3) ELISA Kit |
|||
abx517989-96tests | Abbexa | 96 tests | EUR 801.6 |
Human SDCCAG3(Serologically defined colon cancer antigen 3) ELISA Kit |
|||
EH1858 | FN Test | 96T | EUR 681.12 |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml |
Human SDCCAG3/ Serologically defined colon cancer antigen 3 ELISA Kit |
|||
E2842Hu | Sunlong | 1 Kit | EUR 685.2 |
anti- DEFB4A antibody |
|||
FNab09962 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against DEFB4A |
anti- DEFB4A antibody |
|||
LSMab09962 | Lifescience Market | 100 ug | EUR 463.2 |
anti- DEFB121 antibody |
|||
FNab02328 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against DEFB121 |
Anti-DEFB106A / DEF106B (aa47-59) antibody |
|||
STJ72658 | St John's Laboratory | 100 µg | EUR 312 |
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody |
|||
20-abx311940 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody |
|||
20-abx135805 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
abx234923-100ug | Abbexa | 100 ug | EUR 577.2 |
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
abx234924-100ug | Abbexa | 100 ug | EUR 661.2 |
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody |
|||
abx234926-100ug | Abbexa | 100 ug | EUR 577.2 |
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx211767 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx321660 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
abx331031-100ul | Abbexa | 100 ul | EUR 510 |
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx113577 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody |
|||
20-abx113578 | Abbexa |
|
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Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx324057 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx320117 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
abx431997-200ul | Abbexa | 200 ul | EUR 460.8 |
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx001424 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx015210 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
abx145441-100ug | Abbexa | 100 ug | EUR 469.2 |
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody |
|||
abx145476-100ug | Abbexa | 100 ug | EUR 469.2 |
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody |
|||
20-abx301384 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
20-abx213689 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
20-abx213948 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
20-abx211500 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
20-abx211688 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody |
|||
20-abx211874 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody |
|||
20-abx211875 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
20-abx211876 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
20-abx212135 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody |
|||
20-abx333903 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
abx037320-100ug | Abbexa | 100 ug | EUR 469.2 |
WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
abx033148-400ul | Abbexa | 400 ul | EUR 627.6 |
WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
abx033148-80l | Abbexa | 80 µl | EUR 343.2 |
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
20-abx129026 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody |
|||
20-abx124266 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
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20-abx328331 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
20-abx002006 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody |
|||
20-abx008052 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 3 (WNK3) Antibody |
|||
20-abx004266 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody |
|||
20-abx302326 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody (HRP) |
|||
20-abx311941 | Abbexa |
|
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Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody (HRP) |
|||
20-abx306960 | Abbexa |
|
|
Anti-beta Defensin 1/DEFB1 Antibody |
|||
PA1450 | BosterBio | 100ug/vial | EUR 400.8 |
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody (HRP) |
|||
20-abx316621 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody (FITC) |
|||
20-abx311942 | Abbexa |
|
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WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody (HRP) |
|||
20-abx337640 | Abbexa |
|
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Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody (FITC) |
|||
20-abx306961 | Abbexa |
|
|
IDI1 antibody |
|||
22782-100ul | SAB | 100ul | EUR 468 |
IDI2 Antibody |
|||
39580-100ul | SAB | 100ul | EUR 468 |
IDI1 antibody |
|||
70R-12958 | Fitzgerald | 100 ul | EUR 548.4 |
Description: Affinity purified Rabbit polyclonal IDI1 antibody |
IDI1 antibody |
|||
70R-17881 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal IDI1 antibody |
IDI2 antibody |
|||
70R-17882 | Fitzgerald | 50 ul | EUR 522 |
Description: Rabbit polyclonal IDI2 antibody |
IDI1 antibody |
|||
70R-3705 | Fitzgerald | 50 ug | EUR 560.4 |
Description: Rabbit polyclonal IDI1 antibody raised against the middle region of IDI1 |
IDI2 antibody |
|||
31932-100ul | SAB | 100ul | EUR 302.4 |
IDI2 antibody |
|||
31932-50ul | SAB | 50ul | EUR 224.4 |
IDI1 Antibody |
|||
DF13081 | Affbiotech | 200ul | EUR 420 |
IDI2 Antibody |
|||
1-CSB-PA871603LA01HU | Cusabio |
|
|
Description: A polyclonal antibody against IDI2. Recognizes IDI2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
IDI1 Antibody |
|||
1-CSB-PA010994GA01HU | Cusabio |
|
|
Description: A polyclonal antibody against IDI1. Recognizes IDI1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
IDI2 Antibody |
|||
1-CSB-PA010995GA01HU | Cusabio |
|
|
Description: A polyclonal antibody against IDI2. Recognizes IDI2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody (FITC) |
|||
20-abx316622 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody (FITC) |
|||
20-abx337641 | Abbexa |
|
|
Anti-Alpha Defensin 1/DEFA1 Antibody |
|||
A10546 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-DEFB107A / DEFB107B antibody |
|||
STJ72659 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-DEFB103A / DEFB103B antibody |
|||
STJ72660 | St John's Laboratory | 100 µg | EUR 312 |
Polyclonal Goat Anti-IBP / DEF6 Antibody |
|||
APR16306G | Leading Biology | 0.1 mg | EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-IBP / DEF6 . This antibody is tested and proven to work in the following applications: |
Mitotic Arrest Deficient 2 Like 2 (MAD2L2) Antibody (Biotin) |
|||
20-abx311943 | Abbexa |
|
|
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) Antibody (Biotin) |
|||
20-abx306962 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
abx235058-100ug | Abbexa | 100 ug | EUR 577.2 |
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
abx235059-100ug | Abbexa | 100 ug | EUR 577.2 |
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx235060-100ug | Abbexa | 100 ug | EUR 577.2 |
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
abx235062-100ug | Abbexa | 100 ug | EUR 577.2 |
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx225288 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx109729 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx173582 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx173583 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx177570 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx177571 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx212230 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx212332 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx212341 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx212359 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx212363 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx213180 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx213339 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx210542 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx211913 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx325822 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx321528 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx321722 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx322275 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx332335-100ul | Abbexa | 100 ul | EUR 510 |
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx332336-100ul | Abbexa | 100 ul | EUR 510 |
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
abx332447-100ul | Abbexa | 100 ul | EUR 510 |
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx326200 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx327610 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx113755 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx113756 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx113758 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx113759 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx113761 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
abx027744-400ul | Abbexa | 400 ul | EUR 627.6 |
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
abx027744-80l | Abbexa | 80 µl | EUR 343.2 |
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
abx028121-400ul | Abbexa | 400 ul | EUR 627.6 |
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
abx028121-80l | Abbexa | 80 µl | EUR 343.2 |
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
abx028737-400ul | Abbexa | 400 ul | EUR 627.6 |
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
abx028737-80l | Abbexa | 80 µl | EUR 343.2 |
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx126969 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx128636 | Abbexa |
|
|
Minichromosome Maintenance Deficient 2 (MCM2) Antibody |
|||
20-abx129081 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx323744 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx338830 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx320233 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx329450 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx432951-200ul | Abbexa | 200 ul | EUR 343.2 |
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx432952-200ul | Abbexa | 200 ul | EUR 343.2 |
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx002188 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody |
|||
20-abx009002 | Abbexa |
|
|
Minichromosome Maintenance Deficient 3 (MCM3) Antibody |
|||
20-abx000983 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
20-abx001052 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx004255 | Abbexa |
|
|
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
20-abx013138 | Abbexa |
|
|
Minichromosome Maintenance Deficient 7 (MCM7) Antibody |
|||
abx145477-100ug | Abbexa | 100 ug | EUR 469.2 |
Minichromosome Maintenance Deficient 5 (MCM5) Antibody |
|||
abx145478-100ug | Abbexa | 100 ug | EUR 469.2 |
WNK Lysine Deficient Protein Kinase 1 (WNK1) Antibody (Biotin) |
|||
20-abx316623 | Abbexa |
|
|
WNK Lysine Deficient Protein Kinase 2 (WNK2) Antibody (Biotin) |
|||
20-abx337642 | Abbexa |
|
|
SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) Antibody |
|||
20-abx129130 | Abbexa |
|
|
Sco Cytochrome Oxidase Deficient Homolog 1 (Yeast) Antibody |
|||
20-abx115390 | Abbexa |
|
|
Sco Cytochrome Oxidase Deficient Homolog 2 (Yeast) Antibody |
|||
20-abx115391 | Abbexa |
|
|
Minichromosome Maintenance Deficient 4 (MCM4) Antibody (HRP) |
|||
20-abx335415 | Abbexa |
|
|
Switching b/tsDMARDs could also be a proxy for increased illness severity or poorly managed RA and an vital confounder to contemplate in acquiring unbiased estimates of VTE danger in observational RA security research.

Cardiovascular danger of synthetic, non-biologic Disease-Modifying Anti-Rheumatic Drugs (DMARDs).
Patients with rheumatoid ailments have an elevated danger of CVD and CVD-related dying in contrast with the basic inhabitants. Both the conventional cardiovascular danger elements and systemic irritation are contributors to this phenomenon. This evaluate examines the obtainable proof about the results of synthetic, non-biologic disease-modifying antirheumatic drugs (DMARDs) in CVD danger.
This is a crucial situation for clinicians when deciding on particular person remedy plans in patients with rheumatic ailments. Evidence means that synthetic, non-biologic DMARDs similar to methotrexate, sulfosalazine, hydroxychloroquine, leflunomide and tofacitinib present decreased CVD morbidity and mortality. However, the strongest knowledge in favor of a discount in CVD occasions in rheumatoid patients are proven with methotrexate which has been the focus of most research.
Adequate proof for a beneficial impact additionally exists for hydroxychlorokine. Larger, potential research and randomized scientific trials are wanted to raised characterize the impact of synthetic, non-biologic DMARDs on CVD outcomes in these patients.
Design of future research ought to embody areas with lack of proof, similar to the danger for coronary heart failure, arrhythmias and valvular coronary heart illness. The clinically related query whether or not synthetic, non-biologic DMARDs are inferior to biologic DMARDs in phrases of CVD outcomes nonetheless stays not adequately addressed.