Resistance of Synthetic and Biologic Surgical Meshes to Methicillin-Resistant Staphylococcus aureus Biofilm: An In Vitro Investigation.

Resistance of Synthetic and Biologic Surgical Meshes to Methicillin-Resistant Staphylococcus aureus Biofilm: An In Vitro Investigation.

Surgical meshes have develop into the usual process for a spread of surgical purposes with 20 million meshes being implanted every year. The reputation of mesh utilization amongst surgeons is backed by the a number of research that assist its performance as a software for bettering surgical outcomes.

However, their use has additionally been related to infectious surgical issues and many surgeons have turned to biologic meshes. While there have been a number of research investigating artificial meshes, there may be restricted knowledge evaluating artificial and biologic meshes in vitro in an an infection mannequin. This examine evaluates the in vitro susceptibility of each artificial and biologic meshes to single-species methicillin-resistant Staphylococcus aureus (MRSA) biofilms.

This analysis compares biofilm biomass, common thickness, and protection between the three meshes via florescent in situ hybridization (FISH), confocal scanning microscopy (CSLM), and picture evaluation. We additionally report the various ranges of planktonic and connected micro organism via sonication and cfu counts. While the information illustrates elevated biofilm formation on biologic mesh in vitro, the examine should additional be investigated in vivo to affirm the examine observations.

Resistance of Synthetic and Biologic Surgical Meshes to Methicillin-Resistant Staphylococcus aureus Biofilm: An In Vitro Investigation.
Resistance of Synthetic and Biologic Surgical Meshes to Methicillin-Resistant Staphylococcus aureus Biofilm: An In Vitro Investigation.

Synovial Tissue Heterogeneity in Rheumatoid Arthritis and Changes With Biologic and Targeted Synthetic Therapies to Inform Stratified Therapy.

The therapy of rheumatoid arthritis (RA) has been reworked with the introduction of biologic illness modifying anti-rheumatic medicine (bDMARD) and extra just lately, focused artificial DMARD (tsDMARD) therapies within the kind of janus-kinase inhibitors. Nevertheless, response to these brokers varies such {that a} trial and error method is adopted; main to poor affected person high quality of life, and long-term outcomes. There is thus an pressing want to determine efficient biomarkers to information therapy choice. A wealth of analysis has been invested on this area however with minimal progress.

Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-50ug

QP8982-ye-50ug 50ug
EUR 500.4

Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-100ug

QP8982-ye-100ug 100ug
EUR 804

Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-200ug

QP8982-ye-200ug 200ug
EUR 1282.8

Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-500ug

QP8982-ye-500ug 500ug
EUR 2164.8

Annexin VII (Annexin VII) Antibody

abx230439-100ug 100 ug
EUR 610.8

Horse ANX5(Annexin 5) ELISA Kit

EHS0047 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Horse;Sensitivity: 0.938 ng/ml

Annexin VIII (Annexin VIII) Antibody

abx230440-100ug 100 ug
EUR 577.2

Annexin A1

PR27207 2 ug
EUR 465.6

Annexin A2

PR27211 5 ug
EUR 229.2

Annexin A3

PR27212 5 ug
EUR 229.2

Annexin A4

PR27213 2 ug
EUR 229.2

Annexin A5

PR27214 5 ug
EUR 229.2

Annexin A6

PR27215 2 ug
EUR 229.2

Annexin A7

PR27216 5 ug
EUR 229.2

Annexin A8

PR27217 5 ug
EUR 229.2

Annexin A10

PR27208 5 ug
EUR 229.2

Annexin A11

PR27209 5 ug
EUR 229.2

Annexin A13

PR27210 2 ug
EUR 229.2

Recombinant human Annexin A5/Annexin V/ANXA5 Protein

RP01180 10 μg
EUR 186

Annexin Peptide

45-007P 0.1 mg
EUR 405.6
Description: (NT) Annexin A11 Peptide

Annexin Peptide

45-008P 0.1 mg
EUR 405.6
Description: (NT) Annexin A2 Peptide

Annexin V (PE)

abx090613-100tests 100 tests
EUR 644.4

Annexin V PE

EXB0027 100 tests
EUR 244.8

Annexin V (APC)

abx090615-100tests 100 tests
EUR 718.8

Annexin V APC

EXB0028 100 tests
EUR 244.8

Annexin-2 Antibody

39396-100ul 100ul
EUR 468

Polyclonal ANXA6/Annexin A6/Annexin VI Antibody (aa1-50)

APR02865G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ANXA6/Annexin A6/Annexin VI (aa1-50). This antibody is tested and proven to work in the following applications:

Annexin V (FITC)

abx090611-100tests 100 tests
EUR 510

Annexin V FITC

EXB0024 100 tests
EUR 244.8

Annexin V, CF770

29046 25ug
EUR 410.4
Description: Minimum order quantity: 1 unit of 25ug

Annexin V, CF790

29047 25ug
EUR 439.2
Description: Minimum order quantity: 1 unit of 25ug

Annexin A3 siRNA

20-abx907669
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Annexin A3 siRNA

20-abx907670
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Annexin V siRNA

20-abx907673
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Annexin V siRNA

20-abx907674
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Annexin A3 siRNA

20-abx900342
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Annexin V siRNA

20-abx900343
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

ANXA1 (Annexin A1)

MO47023 100 ul
EUR 418.8

Annexin A2/ANXA2

E21-205 10ug
EUR 411.6

Annexin V, sulforhodamine 101 conjugate (Texas-Red Annexin V)

29002 0.5ML
EUR 332.4
Description: Minimum order quantity: 1 unit of 0.5ML

Annexin A5 Protein

20-abx260555
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Annexin A3 Protein

20-abx260563
  • EUR 3433.20
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Annexin A7 Protein

20-abx261405
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Annexin A8 Protein

20-abx261421
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Annexin A4 Protein

20-abx262872
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Annexin A6 Protein

20-abx262873
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Annexin A1 protein

30R-1291 20 ug
EUR 548.4
Description: Purified recombinant Human Annexin A1 protein

Annexin A5 protein

30R-1406 100 ug
EUR 321.6
Description: Purified recombinant Human Annexin A5 protein

Annexin A3 protein

30R-1453 100 ug
EUR 321.6
Description: Purified recombinant Human Annexin A3 protein

Annexin A4 protein

30R-1463 100 ug
EUR 703.2
Description: Purified recombinant Human Annexin A4 protein

Annexin A5 protein

30R-3209 50 ug
EUR 308.4
Description: Purified recombinant Annexin A5 protein

Annexin A3 Protein

abx061599-200ug 200 ug
EUR 1528.8

Annexin A1 Peptide

46-785P 0.1 mg
EUR 405.6
Description: ANXA1 Peptide

Annexin A13 Protein

20-abx261320
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Annexin IV Antibody

AF7586 200ul
EUR 540

Annexin A2 Antibody

AF7596 200ul
EUR 540

Annexin A2 Antibody

AF7597 200ul
EUR 540

Annexin I antibody

10-2468 250 ug
EUR 590.4
Description: Mouse monoclonal Annexin I antibody

Annexin I antibody

10-2469 250 ug
EUR 590.4
Description: Mouse monoclonal Annexin I antibody

Annexin 1 antibody

10R-11422 100 ul
EUR 418.8
Description: Mouse Monoclonal Annexin 1 antibody

Annexin V antibody

10R-7939 100 ug
EUR 516
Description: Mouse monoclonal Annexin V antibody

Annexin VI Antibody

21672-100ul 100ul
EUR 302.4

Annexin VI Antibody

21672-50ul 50ul
EUR 224.4

Annexin A1 antibody

22818-100ul 100ul
EUR 468

Annexin V antibody

20R-1522 100 ug
EUR 781.2
Description: Rabbit polyclonal Annexin V antibody

Annexin A5 Antibody

39410-100ul 100ul
EUR 468

Annexin A2 Antibody

39291-100ul 100ul
EUR 468

Annexin A10 Peptide

45-255P 0.1 mg
EUR 405.6
Description: Annexin A10 / Annexin 14 Peptide

Annexin A6 antibody

70R-31098 100 ug
EUR 392.4
Description: Rabbit polyclonal Annexin A6 antibody

Annexin A6 Antibody

AF0116 200ul
EUR 420

Annexin A1 Antibody

AF5154 200ul
EUR 420

Annexin A2 Antibody

AF5171 200ul
EUR 420

Annexin A1 Antibody

AF5328 200ul
EUR 420

Annexin A2 Antibody

AF5420 200ul
EUR 420

Annexin V antibody

70R-11770 100 ug
EUR 632.4
Description: Rabbit polyclonal Annexin V antibody

Annexin V Antibody

49376-100ul 100ul
EUR 399.6

Annexin V Antibody

49376-50ul 50ul
EUR 286.8

Annexin A2 Antibody

49559-100ul 100ul
EUR 399.6

Annexin A2 Antibody

49559-50ul 50ul
EUR 286.8

Annexin A7 antibody

70R-1680 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A7 antibody raised against the N terminal of ANXA7

Annexin A1 antibody

70R-1703 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A1 antibody raised against the N terminal of ANXA1

Annexin A1 antibody

70R-13525 100 ul
EUR 548.4
Description: Affinity purified Rabbit polyclonal Annexin A1 antibody

Annexin I antibody

70R-13689 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin I antibody

Annexin IV antibody

70R-13690 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin IV antibody

Annexin V antibody

70R-13691 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin V antibody

Annexin A2 antibody

70R-13890 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin A2 antibody

Annexin A6 antibody

70R-13975 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin A6 antibody

Annexin A8 antibody

70R-14039 100 ug
EUR 418.8
Description: Affinity purified Rabbit polyclonal Annexin A8 antibody

Annexin A3 antibody

70R-14049 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Annexin A3 antibody

Annexin A2 antibody

70R-15166 100 ug
EUR 392.4
Description: Rabbit polyclonal Annexin A2 antibody

Annexin A5 antibody

70R-15224 100 ug
EUR 392.4
Description: Rabbit polyclonal Annexin A5 antibody

Annexin A7 antibody

70R-1667 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A7 antibody raised against the N terminal of ANXA7

Annexin A5 antibody

70R-1668 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A5 antibody raised against the N terminal of ANXA5

Annexin A5 antibody

70R-1669 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A5 antibody raised against the N terminal of ANXA5

Annexin A6 antibody

70R-1672 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A6 antibody raised against the C terminal of ANXA6

Annexin A6 antibody

70R-1673 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A6 antibody raised against the N terminal of ANXA6

Annexin A4 antibody

70R-1676 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A4 antibody raised against the N terminal of ANXA4

Annexin A3 antibody

70R-1677 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A3 antibody raised against the N terminal of ANXA3

Annexin A3 antibody

70R-1678 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A3 antibody raised against the C terminal of ANXA3

Annexin A2 antibody

70R-1679 100 ug
EUR 452.4
Description: Rabbit polyclonal Annexin A2 antibody raised against the C terminal of ANXA2

Annexin A4 antibody

70R-6041 50 ug
EUR 560.4
Description: Rabbit polyclonal Annexin A4 antibody raised against the middle region of ANXA4

Annexin A2 antibody

70R-51447 100 ul
EUR 344.4
Description: Purified Polyclonal Annexin A2 antibody

Annexin A1 antibody

70R-49368 100 ul
EUR 292.8
Description: Purified Polyclonal Annexin A1 antibody

Annexin A2 antibody

70R-49369 100 ul
EUR 292.8
Description: Purified Polyclonal Annexin A2 antibody

Annexin A3 antibody

70R-49370 100 ul
EUR 292.8
Description: Purified Polyclonal Annexin A3 antibody

Annexin A6 antibody

70R-49371 100 ul
EUR 292.8
Description: Purified Polyclonal Annexin A6 antibody

Annexin V Antibody

3357-100 each
EUR 464.4

Annexin V Antibody

3357-30T each
EUR 175.2

Annexin XI Antibody

35334-100ul 100ul
EUR 468

Annexin A6 Antibody

33322-100ul 100ul
EUR 302.4

Annexin A6 Antibody

33322-50ul 50ul
EUR 224.4

Annexin A3 Antibody

48531-100ul 100ul
EUR 399.6

Annexin A3 Antibody

48531-50ul 50ul
EUR 286.8

Annexin IV Antibody

49926-100ul 100ul
EUR 399.6

Annexin IV Antibody

49926-50ul 50ul
EUR 286.8

Annexin A6 Antibody

ABF0116 100 ug
EUR 525.6

Annexin?I Antibody

ABF5154 100 ug
EUR 525.6

Annexin II Antibody

ABF5171 100 ug
EUR 525.6

Annexin V Antibody

DF6580 200ul
EUR 420

Annexin IV Antibody

DF8068 200ul
EUR 420

Annexin A1 Antibody

DF6254 200ul
EUR 420

Annexin A2 Antibody

DF6468 200ul
EUR 420

Annexin A5 Antibody

1-CSB-PA001846HA01EQC
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Annexin A5. Recognizes Annexin A5 from Cynops pyrrhogaster. This antibody is Unconjugated. Tested in the following application: ELISA

Annexin V Antibody

F49706-0.08ML 0.08 ml
EUR 140.25
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.

Annexin V Antibody

F49706-0.4ML 0.4 ml
EUR 322.15
Description: Annexin 5 belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII.

Annexin V Antibody

F49707-0.08ML 0.08 ml
EUR 140.25
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]

Annexin V Antibody

F49707-0.4ML 0.4 ml
EUR 322.15
Description: Annexin 5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. [UniProt]

Annexin A1 Antibody

F49712-0.08ML 0.08 ml
EUR 140.25
Description: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

Annexin A1 Antibody

F49712-0.4ML 0.4 ml
EUR 322.15
Description: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

Annexin V antibody

PAab09988 100 ug
EUR 463.2

Annexin A1 Antibody

P1024-01m 0.1m
EUR 242.4

Annexin A1 Antibody

P1024-1ml 1ml
EUR 529.2

Annexin A1 Antibody

R30173 100 ug
EUR 356.15
Description: Annexin I, also known as lipocortin I(Lipo1), belongs to the family of annexins. These proteins are though to control the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes. In two lipocortins(I and II) a short amino-terminal sequence distinct from the core structure has potential regulatory functions which are dependent on its phosphorylation state. The gene in the mouse encodes a protein of 346 amino acid residues. Mouse Lipo1 gene spans about 17 kb and is divided into 13 exons. Annexin I gene, mapped to 9q11-q22, is located on mouse chromosome 19. Annexin I acts through the formyl peptide receptor on human neutrophils. Peptides derived from the unique N-terminal domain of annexin I serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner.

Annexin V Antibody

R30176 100 ug
EUR 356.15
Description: Annexin V is also know as endonnexin II (ENX2),or placental protein 4 (PP4). It is a member of the family of Ca(2+)-dependent phospholipid binding proteins, known as annexins. It bind to the phospholipids that are preferentially located on the cytosolic face of the plasma membrane. Annexin V has a relative molecular weight of about 35,000. The gene lies on mouse chromosome 3 in close linkage with the fibroblast growth factor 2(basic) gene and is syntenic with other genes known to have orthologous counterparts on human chromosome 4q. The cDNA encoded a protein of 320 amino acid residues. A single mRNA, approximately 1.6 kb long, was found to be expressed in human cell lines and placenta. It is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Annexin A2 Antibody

R30414 100 ug
EUR 356.15
Description: Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. The ANXA2 gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Richard et al.(1994) presented an integration of the physical, expression, and genetic maps of human chromosome 15. They placed the ANXA2 gene in their region IV, i.e., 15q21-q22, thus confirming the previous localization.

Annexin VI Antibody

R30506 100 ug
EUR 356.15
Description: Annexin VI (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization.The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal.Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion

Annexin A3 Antibody

R30583 100 ug
EUR 356.15
Description: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The gene contains 13 exons and spans 58 kb of genomic DNA and is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.

Annexin V Antibody

R31475 100 ug
EUR 356.15
Description: Annexin V or A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. This protein is an anticoagulant protein, it can form a shield around negatively-charged phospholipid molecules, the formation of an Annexin V shield blocks the entry of phospholipids into coagulation (clotting) reactions. Annexin AV can also act as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Annexin A1 Antibody

R31548 100 ug
EUR 356.15
Description: ANXA1, also known as Lipocortin I or Annexin A1, is a protein that in humans is encoded by the ANXA1 gene. It is mapped to 9q21.13. It belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. ANXA1 protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

Annexin A3 Antibody

R31948 100 ug
EUR 356.15
Description: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.

Annexin IV Antibody

R32677 100ug
EUR 356.15
Description: ANXA4 (Annexin A4), also known as ANX4, is a protein that in humans is encoded by the ANXA4 gene. It belongs to the annexin family of calcium-dependent phospholipid binding proteins. By PCR analysis of somatic cell hybrids and in situ hybridization with a cDNA probe, the human ANXA4 gene is mapped to chromosome 2p13. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. And ANXA4 is almost exclusively expressed in epithelial cells.

Annexin A1 Antibody

R33307-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: ANXA1

Annexin A1 Antibody

V3736-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3736-20UG 20 ug
EUR 153.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3736SAF-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3741-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3741-20UG 20 ug
EUR 153.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3741IHC-7ML 7 ml
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V3741SAF-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V7283-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V7283-20UG 20 ug
EUR 153.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V7283IHC-7ML 7 ml
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin A1 Antibody

V7283SAF-100UG 100 ug
EUR 349.3
Description: The ANXA1 gene belongs to the annexin family, and contains 4 annexin repeats. A pair of annexin repeats may form one binding site for calcium and a phospholipid. ANXA1 promotes membrane fusion and is involved in exocytosis. The gene for ANXA1 is upregulated in hairy cell leukemia (HCL), and its protein expression is specific for HCL. Detection of ANXA1 provides a simple, highly sensitive and specific assay for diagnosing HCL. Annexin A1 has also been found to be protective against DNA damage induced by heat in breast cancer cells, suggesting it is involved in tumor suppressive and protective activities, and also is associated with treatment resistance.

Annexin V Antibody

RQ5261 100ul
EUR 356.15
Description: The protein encoded by the ANXA5 gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. [RefSeq]

Annexin VI Antibody

RQ6590 100ug
EUR 356.15
Description: Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca(2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization. The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal. Ca(2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion.

Increasingly acknowledged is the significance of evaluating synovial tissue, the first website of RA, as opposed to peripheral blood-based investigation. In this mini-review, we summarize the literature supporting synovial tissue heterogeneity, the conceptual foundation for stratified remedy. This consists of recognition of distinct synovial pathobiological subtypes and related molecular pathways.

We additionally evaluate synovial tissue research which were carried out to consider the impact of particular person bDMARD and tsDMARD on the mobile and molecular traits, with a view to figuring out tissue predictors of response. Initial observations are being introduced into the medical trial panorama with stratified biopsy trials to validate towards implementation. Furthermore, improvement of tissue based mostly omics know-how holds nonetheless extra promise in advancing our understanding of illness processes and guiding future drug choice.

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