Downregulation of endothelial nitric oxide synthase (eNOS) and endothelin–1 (ET–1) in a co-culture system with human stimulated X-linked CGD neutrophils.
Phagocytes in patients with chronic granulomatous disease (CGD) do not generate reactive oxidative species (ROS), whereas nitric oxide (NO) production is increased in response to the calcium ionophore A23187 in CGD phagocytes compared with healthy phagocytes. Recently, patients with X-linked CGD (X-CGD) have been reported to show higher flow-mediated dilation, suggesting that endothelial cell function …